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HCP Analysis by ELISA and Orthogonal Methods
in Vaccine and Gene Therapy Development

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Presenter:

jared-isaac-150x190
Jared Isaac, PhD
Sr. Scientist, Chromatography and Mass Spectrometry
Cygnus Technologies
 
Dr. Jared Isaac currently leads Cygnus Technologies’ Chromatography and Mass Spectrometry services for identification and quantification of host cell proteins (HCPs). Trained in liquid chromatography with mass spectrometry (LC-MS) proteomics at Thermo Fisher Scientific, he is an expert in qualitative and quantitative mass spectrometry methods for biopharmaceutical process impurities. Jared utilizes Antibody Affinity Extraction (AAE) in combination with fast-protein liquid chromatography (FPLC), ultrahigh-pressure liquid chromatography (UHPLC), two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), and mass spectrometry to enable biopharmaceutical companies to determine whether Cygnus Technologies’ HCP enzyme-linked immunosorbent assay (ELISA) antibodies have sufficient coverage for the HCPs in their downstream purification process and assess HCP profile in final drug substances. Jared earned his PhD in Biomedical Science from the University of Cincinnati and his MBA from Western Michigan University. He has over eight years of industry experience.