About this event:

Date: May 14, 2026

Time: 11 AM EDT | 8 AM PDT

5 PM CEST

Duration: 30 minutes

Antibody-based therapeutics are rapidly advancing toward more complex formats such as bispecific antibodies (BsAbs), with the promise of improved targeting and efficacy. However, this increased complexity introduces significant downstream challenges, particularly in the formation and removal of diverse product-related impurities.

During upstream processing, BsAb expression can generate multiple product variants, including homodimers, light-chain mispaired species, half antibodies, fragments, and aggregates. These species often exhibit similar physicochemical properties to the target molecule, limiting the effectiveness of standard platform purification approaches and necessitating more targeted, mechanism-driven process development strategies.

This webcast will share practical, data-driven approaches for designing purification processes tailored to BsAbs, drawing on published literature and case studies to illustrate how alternative capture and polishing strategies can be applied to help enable improved separation and target purity.

Key Takeaways:

• An overview of common BsAb impurity profiles and their impact on downstream processing

• Literature-based examples of chromatographic strategies for resolving product-related variants

• Considerations for selecting and operating affinity, ion exchange, and mixed-mode chromatography techniques.