Lipid nanoparticles (LNPs) have emerged as powerful drug delivery systems capable of encapsulating a wide range of nucleic acid payloads. They offer key advantages such as protection of RNA from degradation, enhanced cellular uptake, and controlled release—making them highly promising for therapeutic applications, including mRNA vaccines and gene therapies.

Accurate and robust analytical methods are essential to ensure the quality, efficacy, and safety of LNP-based drug products. Liquid chromatography serves as a powerful tool to assess these properties, offering high-resolution insights into both nucleic acid and lipid components.

In this webinar, Sartorius BIA Separations presents a specialized chromatographic tool—the LNP Analytical Platform—designed for comprehensive characterization of RNA-LNP drug products. Case studies will demonstrate the application of the PATfix system across multiple stages of mRNA vaccine manufacturing.

Key Takeaways:

• Use chromatography to analyze lipid nanoparticle-based therapeutics.
• Understand drug product beyond the size and encapsulation efficiency.
• Learn innovative methods for analysis that do not require sample pre-treatment for separate component analysis.