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title: Innovation of Novel Purification Strategies – A Case Study of a Clusterin Scavenger Resin
description: In this webinar, learn about a novel scavenging resin for clusterin, a persistent CHO host cell protein commonly observed in MAb manufacturing processes.
---

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# Innovation of Novel Purification

# Strategies – A Case Study of a

# Clusterin Scavenger Resin

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## Presenter:

****![NickRandall](https://bpi.bioprocessintl.com/hs-fs/hubfs/2-28-23-Thermo-ATE-Manuel-Matos-HS-Cropped.png?width=147&height=221&name=2-28-23-Thermo-ATE-Manuel-Matos-HS-Cropped.png)****

**Manuel Matos, PhD**

*Field Application Scientist,*

Thermo Fisher Scientific

 

Manuel Matos is a field application scientist, specializing in downstream processing development of antibodies, recombinant proteins, and viral vectors. Manuel holds a bachelor's degree in biochemistry from the University of Coimbra and a master's degree in biotechnology from the NOVA School of Science and Technology.

 

In 2021, Manuel was awarded his doctoral degree in bioengineering systems from MIT Portugal, where he developed artificial scaffolds for the affinity separation of biomolecules. Following his studies, Manuel worked at Fairjourney Biologics and Rodon Biologics as a research scientist, where he developed experience in the process development of MAbs.

## About this event:

#### Date: May 23, 2023

#### Time: 11 am EDT | 8 am PDT | 5 pm CET

#### Duration: 15 minutes

Affinity chromatography resins employ target-specific ligands attached to a stationary phase and are commonly used to capture therapeutic entities in biologics manufacturing, reducing the number of required purification steps and increasing overall yield.

A less common but powerful use of affinity purification is the removal of problematic impurities, such as host cell proteins. Both techniques require high-specificity affinity ligands with sufficient capacity, stability, and suitability for clinical manufacturing.

In this webinar, we present the development of a novel scavenging resin for clusterin, a persistent CHO host cell protein commonly observed in monoclonal antibody manufacturing processes.

Key Takeaways:

- Understand platform process for the generation of highly specific VHH antibody-based ligands and affinity resin development for bioproduction.
- Analyze performance data and sample chromatography condition for POROSTM CaptureSelectTM ClusterinClear affinity resin.
- Review custom resin development process and timeline.

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