---
title: "Introducing Super Refined Poloxamer 188: Optimized for Mammalian Cell Culture with Exceptional Batch-to-Batch Consistency"
description: In this webinar, learn about Super Refined™ Poloxamer 188 and how it's optimized for mammalian cell culture with exceptional batch-to-batch consistency.
---

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# Introducing Super Refined™ Poloxamer 188: Optimized for Mammalian Cell Culture with Exceptional Batch-to-Batch Consistency

 

## Presenters:

****![James Humphrey](https://bpi.bioprocessintl.com/hs-fs/hubfs/James%20Humphrey.png?width=136&height=139&name=James%20Humphrey.png)****

** James Humphrey**

*Research and Technology Specialist,*

Croda Pharma

 

James Humphrey has over 15 years’ experience focusing on the formulation sector. Whilst at Croda, he has pioneered formulation projects using Croda’s current range of surfactants, along with leading the new product innovation. James has a great interest on the role of the excipient type and quality on the stability and delivery of drugs of differing modalities in numerous dosage forms.

 

****![Garima Sinha](https://bpi.bioprocessintl.com/hs-fs/hubfs/Garima%20Sinha.png?width=136&height=145&name=Garima%20Sinha.png)****

**Garima Sinha**

*Lead Applications Scientist,*

Croda Pharma

 

Garima Sinha is currently the Lead Application Scientist on Croda Pharma’s data development team in North America. She received her PhD in Biomedical Science from Rutgers University, followed by a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center in New York. Dr. Sinha has been with Croda for around two and half years, collaborating with different groups within the company’s pharma team on both existing and newly developed products that benefit both the bioprocessing and pharmaceutical industries. 

 

****![Jessica Santa Maria](https://bpi.bioprocessintl.com/hs-fs/hubfs/Jessica%20Santa%20Maria.png?width=136&height=130&name=Jessica%20Santa%20Maria.png)****

** Jessica Santa Maria**

*Technical Marketing Lead,*

Croda Pharma

 

Jessica Santa Maria is a global Technical Marketing Lead for Croda Pharma’s Small Molecule and Protein Delivery platforms. She holds a BS in Biochemistry and Nutritional Sciences, as well as an MBA in Pharmaceutical Management and Marketing, both from Rutgers University. Jessica has over six years of combined benchtop experience in cancer cell biology and pharmacogenomics research before joining Croda. In her current role, Jessica leads cross-functional teams to support new product development.

 

 

## About this event:

#### Date: October 29, 2024

#### Time: 11 am EDT | 8 am PDT | 5 pm CEST

#### Duration: 60 minutes

| Poloxamer 188 is a surfactant with a longstanding history of use in pharmaceutical drugs, spanning dosage routes from oral to topical and parenteral administration. In the biomanufacturing space, it finds application not only as a surfactant for parenteral biological formulations, but also in cell culture as a shear stress protectant. Its specific surfactant properties make it effective at stabilizing proteins, as well as protecting cells from shear stress caused by agitation in a bioreactor. Poloxamer 188 has the ability to prevent cell shear stress due to its specific balance of hydrophobic PPO chain flanked by two blocks of hydrophilic PEO. However, impurities from the manufacturing process can compromise its performance, leading to detrimental effects on cell health and contributing to batch-batch inconsistency. One persistent challenge in the market has been the search for reliable manufacturers of poloxamer 188 with the ability to produce consistent materials exhibiting consistent batch-to-batch performance, with dependable outcomes in biomanufacturing processes. This challenge has led to the development of  Super Refined™ Poloxamer 188, which our presenters will share more about in this webinar. Optimized specifically for mammalian cell culture, Super Refined™ Poloxamer 188 offers excellent cell culture performance, with highly controlled impurity profiles that de-risk variable cell performance from batch-to-batch. We will demonstrate exceptional performance in cell viability performance against competitor materials in both CHO and HEK suspension lines, present data highlighting batch-to-batch consistency in performance along with supporting analytical data on the poloxamer compositional and impurity profile. |
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